Relation of Methemoglobin to Hernolysis
نویسنده
چکیده
IT IS \VELL KNO\VN that a number of chemical agents, w’hieh under certain circumstances cause intravascular hemolvsis an(l the development of hemolytic anemia, also produce methemoglobinemia. Some examples of these agents are stllfanilam ide, phenylhydrazine, aniline , acetanilid, p-aminophenol , plasmochin, etc. Such a correlation may lead to the inference that intracorpu.scular methemoglobin is related in some way to the process of hemolysis. It has been observed that. the dosage level of acetanilid and acetophenet.idin causing significant anemia also exceeds the threshold for methemoglobin formation.’ The data of Rimington and Hemmings2 might also he interpreted to lend some additional support to the view’ that methemoglobin plays some positive role. In studies on drugs related to sulfanilamide, they observed a close correlation between the action of aromatic amino compounds to increase porphyrin excretion and to form met.hemoglohin. Since the increased porphyrin excretion in rodent.s was due largely to coproporphyrin III, it has been suggested that this represents an abnormal pathw’ay for the degradation of hemoglobin possibly through methemoglobin.2 ‘ However, Rimington and Hemmings2 w’ere not certain as to the role of the methemoglobin in either the increased erythrocyte destruction or the increased porphyrin excretion since the latter w’as not observed after sodium nitrite administration, which readily produces methemoglobin. Fox and Ottenberg4 studying the hemolytic anemias from sulfonamides in man observed a
منابع مشابه
Development of methemoglobin-based biological dosimetry in gamma–irradiated mice
Background: A new biological dosimeter based on methemoglobin level was developed in this study. Materials and Methods: Methemoglobin level in erythrocytes from mice subjected to &gamma rays from a 60Co source was detected using the methemoglobin kit. The dose range was from 0.5 to 8 Gy and the dose rate was 0.5 Gy/min. Results: The results demonstrate that methemoglobin level increases with in...
متن کاملFructation Induces Hemin Degradation in Methemoglobin
Under prolonged diabetic conditions, HbA1c is produced from normal hemoglobin (HbA0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (metHb). Here we are reporting that the non-enzymatic reaction between fructose and metHb (metHb fructation) induces significant changes in the gl...
متن کاملAntioxidant effect of different vitamins on methemoglobin production: An in vitro study
Nitrite intoxication occurs frequently in ruminants and equines. The most common treatment of this disorder is administration of 1% methylene blue, although the use of some antioxidant agents e.g. vitamins and complementary treatment may also be useful. The aim of this study was to evaluate the in vitro antioxidative effects of some vitamins on methemoglobinemia induced by sodium nitrite. For t...
متن کاملStudies of Methemoglobin Concentrations of Three Human Erythrocyte Genotypes (Hb AA, Hb AS, and Hb SS) in the Presence of Five Antimalarial Drugs
Background: Malaria remains the world’s most devastating human parasitic infection. Our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (FansidarTM, HalfanTM, Quinine, CoartemTM and Chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (Hb AA, Hb AS and Hb SS). Materials and Methods: Spectrophotometric metho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005